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XB-ART-17187
Development January 1, 1997; 124 (2): 373-9.

An essential role for retinoid signaling in anteroposterior neural patterning.

Blumberg B , Bolado J , Moreno TA , Kintner C , Evans RM , Papalopulu N .


Abstract
The vertebrate central nervous system (CNS) is induced by signals emanating from the dorsal mesoderm, or organizer, that divert the ectoderm away from an epidermal and towards a neural fate. Additional signals from the organizer pattern the neural ectoderm along the anteroposterior axis. We devised highly specific methods utilizing constitutively active or dominant negative receptors to evaluate the role of retinoids in neural patterning. Microinjection of these reagents either augments or reduces retinoid signaling in specific regions of the embryo. We show that increased receptor activity suppresses anterior neural structures while dominant negative receptors lead to anterior enhancement. Similarly, microinjection of the dominant negative receptor leads to the loss of posterior marker genes. We demonstrate that retinoid receptors comprise a critical component in neural posteriorization and are required for proper neuronal differentiation. These results support a quantitative role for retinoid signaling in regionalization of the CNS.

PubMed ID: 9053313
Article link: Development
Grant support: [+]
Genes referenced: egr2 en2 gal.2 lhx1 otx2 rarb tbx2 tra


Article Images: [+] show captions


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