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XB-ART-17245
Cell December 27, 1996; 87 (7): 1191-202.

X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation.

Bellefroid EJ , Bourguignon C , Hollemann T , Ma Q , Anderson DJ , Kintner C , Pieler T .


Abstract
X-MyT1 is a C2HC-type zinc finger protein that we find to be involved in the primary selection of neuronal precursor cells in Xenopus. Expression of this gene is positively regulated by the bHLH protein X-NGNR-1 and negatively regulated by the Notch/Delta signal transduction pathway. X-MyT1 is able to promote ectopic neuronal differentiation and to confer insensitivity to lateral inhibition, but only in cooperation with bHLH transcription factors. Inhibition of X-MyT1 function inhibits normal neurogenesis as well as ectopic neurogenesis caused by overexpression of X-NGNR-1. On the basis of these findings, we suggest that X-MyT1 is a novel, essential element in the cascade of events that allows cells to escape lateral inhibition and to enter the pathway that leads to terminal neuronal differentiation.

PubMed ID: 8980226
Article link: Cell


Species referenced: Xenopus laevis
Genes referenced: ascl2 cat.2 dll1 myt1 neurog2 notch1 tubb2b


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