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XB-ART-17426
Science 1996 Nov 15;2745290:1199-201.
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Identification of BIME as a subunit of the anaphase-promoting complex.

Peters JM , King RW , Höög C , Kirschner MW .


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The initiation of anaphase and exit from mitosis require the activation of a proteolytic system that ubiquitinates and degrades cyclin B. The regulated component of this system is a large ubiquitin ligase complex, termed the anaphase-promoting complex (APC) or cyclosome. Purified Xenopus laevis APC was found to be composed of eight major subunits, at least four of which became phosphorylated in mitosis. In addition to CDC27, CDC16, and CDC23, APC contained a homolog of Aspergillus nidulans BIME, a protein essential for anaphase. Because mutation of bimE can bypass the interphase arrest induced by either nimA mutation or unreplicated DNA, it appears that ubiquitination catalyzed by APC may also negatively regulate entry into mitosis.

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Species referenced: Xenopus laevis
Genes referenced: ccnb1.2 cdc16 cdc23 cdc27