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Proc Natl Acad Sci U S A November 12, 1996; 93 (23): 13362-6.

Heteromultimeric CLC chloride channels with novel properties.

Lorenz C , Pusch M , Jentsch TJ .

The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.

PubMed ID: 8917596
PMC ID: PMC24098
Article link: Proc Natl Acad Sci U S A

References [+] :
Ackerman, Cardiac chloride channels. 2011, Pubmed

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