XB-ART-17431Proc Natl Acad Sci U S A November 12, 1996; 93 (23): 13362-6.
Heteromultimeric CLC chloride channels with novel properties.
The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.
PubMed ID: 8917596
PMC ID: PMC24098
Article link: Proc Natl Acad Sci U S A
References [+] :
Ackerman, Cardiac chloride channels. 2011, Pubmed