Perrins R and Soffe SR (1996), Composition of the excitatory drive during swim...

XB-ART-17660

J Comp Physiol A 1996 Oct 01;1794:563-73. doi: 10.1007/bf00192322.

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Composition of the excitatory drive during swimming in two amphibian embryos: Rana and Bufo.

Perrins R , Soffe SR .

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It has recently been shown that spinal neurons in Xenopus embryos receive cholinergic and electrotonic excitation during swimming, in addition to the well documented excitatory amino acid (EAA)-mediated excitation. We have now examined the composition of the excitatory drive during swimming in embryos of two further amphibian species, Rana and Bufo, which have somewhat different motor patterns. Localised applications of antagonists show that presumed motoneurons in Rana and Bufo embryos receive both cholinergic and FAA input during swimming. There is also a further chemical component which is blocked by Cd2+ and a small Cd(2+)-insensitive component, which is usually non-rhythmic. Rhythmic Cd(2+)-insensitive components, presumed to be phasic electrotonic potentials, were only seen in a small proportion of Bufo neurons and in no Rana neurons. While EAA and cholinergic inputs therefore appear to be consistent features of excitatory drive for swimming in amphibian embryo motoneurons, electrotonic input apparently occurs less commonly. Antagonist specificity was tested using applied agonists in Rana. Results of these tests also suggested that the further, unidentified Cd(2+)-sensitive component seen during swimming could represent an incomplete block of AMPA receptor-mediated excitation.

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Species referenced: Xenopus
Genes referenced: fanca

References [+] :

Alford, CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. 1990, Pubmed

Alford, CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. 1990, Pubmed
Alford, Endogenous activation of glycine and NMDA receptors in lamprey spinal cord during fictive locomotion. 1989, Pubmed
Barry, The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick spinal cord. 1987, Pubmed
Birch, 6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor. 1988, Pubmed
Cazalets, Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. 1992, Pubmed
Dale, Dual-component synaptic potentials in the lamprey mediated by excitatory amino acid receptors. 1986, Pubmed
Dale, Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming. 1984, Pubmed , Xenbase
Dale, The Isolation and Identification of Spinal Neurons That Control Movement in the Xenopus Embryo. 1991, Pubmed , Xenbase
Dale, Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos. 1985, Pubmed , Xenbase
Douglas, The effects of intrathecal administration of excitatory amino acid agonists and antagonists on the initiation of locomotion in the adult cat. 1993, Pubmed
Harper, Spinal cord neuron classes in embryos of the smooth newt Triturus vulgaris: a horseradish peroxidase and immunocytochemical study. 1993, Pubmed , Xenbase
Kudo, N-methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb muscles preparation of the newborn rat studied in vitro. 1987, Pubmed
Perrins, Local effects of glycinergic inhibition in the spinal cord motor systems for swimming in amphibian embryos. 1996, Pubmed , Xenbase
Perrins, Cholinergic contribution to excitation in a spinal locomotor central pattern generator in Xenopus embryos. 1995, Pubmed , Xenbase
Perrins, Nicotinic and muscarinic ACh receptors in rhythmically active spinal neurones in the Xenopus laevis embryo. 1994, Pubmed , Xenbase
Perrins, Cholinergic and electrical synapses between synergistic spinal motoneurones in the Xenopus laevis embryo. 1995, Pubmed , Xenbase
Perrins, Cholinergic and electrical motoneuron-to-motoneuron synapses contribute to on-cycle excitation during swimming in Xenopus embryos. 1995, Pubmed , Xenbase
Roberts, Mutual Re-excitation with Post-Inhibitory Rebound: A Simulation Study on the Mechanisms for Locomotor Rhythm Generation in the Spinal Cord of Xenopus Embryos. 1990, Pubmed , Xenbase
Roberts, The neuroanatomy of an amphibian embryo spinal cord. 1982, Pubmed , Xenbase
Roberts, Properties of networks controlling locomotion and significance of voltage dependency of NMDA channels: stimulation study of rhythm generation sustained by positive feedback. 1995, Pubmed , Xenbase
Soffe, Centrally generated rhythmic and non-rhythmic behavioural responses in Rana temporaria embryos. 1991, Pubmed
Soffe, Active and Passive Membrane Properties of Spinal Cord Neurons that Are Rhythmically Active during Swimming in Xenopus Embryos. 1990, Pubmed , Xenbase
Soffe, Patterns of synaptic drive to ventrally located spinal neurones in Rana temporaria embryos during rhythmic and non-rhythmic motor responses. 1991, Pubmed
Soffe, Two distinct rhythmic motor patterns are driven by common premotor and motor neurons in a simple vertebrate spinal cord. 1993, Pubmed , Xenbase
Soffe, Ionic and pharmacological properties of reciprocal inhibition in Xenopus embryo motoneurones. 1987, Pubmed , Xenbase
Verdoorn, N-methyl-D-aspartate/glycine and quisqualate/kainate receptors expressed in Xenopus oocytes: antagonist pharmacology. 1989, Pubmed , Xenbase
Wallén, Phasic variations of extracellular potassium during fictive swimming in the lamprey spinal cord in vitro. 1984, Pubmed