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Proc Natl Acad Sci U S A
1996 Sep 17;9319:10156-61. doi: 10.1073/pnas.93.19.10156.
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Mismatch repair in Xenopus egg extracts: DNA strand breaks act as signals rather than excision points.
Varlet I
,
Canard B
,
Brooks P
,
Cerovic G
,
Radman M
.
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In Xenopus egg extracts, DNA strand breaks (nicks) located 3' or 5' to a mismatch cause an overall 3-fold stimulation of the repair of the mismatch in circular heteroduplex DNA molecules. The increase in mismatch repair is almost entirely due to an increase in repair of the nicked strand, which is stimulated 5-fold. Repair synthesis is centered to the mismatch site, decreases symmetrically on both sides, and its position is not significantly altered by the presence of the nick. Therefore, it appears that in the Xenopus germ cells, the mismatch repair system utilizes nicks as signals for the induction and direction of mismatch repair, but not as the start or end point for excision and resynthesis.
Au,
Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.
1988, Pubmed
Au,
Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.
1988,
Pubmed
Baker,
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis.
1995,
Pubmed
Bayne,
DNA binding protein from ovaries of the frog, Xenopus laevis which promotes concatenation of linear DNA.
1984,
Pubmed
,
Xenbase
Bishop,
Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA.
1989,
Pubmed
Bradford,
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
1976,
Pubmed
Brooks,
Mismatch repair involving localized DNA synthesis in extracts of Xenopus eggs.
1989,
Pubmed
,
Xenbase
Claverys,
Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria.
1986,
Pubmed
Cooper,
Methyl-directed mismatch repair is bidirectional.
1993,
Pubmed
Fang,
Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction.
1993,
Pubmed
Fishel,
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
1993,
Pubmed
Fox,
Some features of genetic recombination in procaryotes.
1978,
Pubmed
Grilley,
Bidirectional excision in methyl-directed mismatch repair.
1993,
Pubmed
Gurdon,
Gene transfer in amphibian eggs and oocytes.
1981,
Pubmed
Herendeen,
A transcriptional enhancer whose function imposes a requirement that proteins track along DNA.
1992,
Pubmed
Hollingsworth,
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.
1995,
Pubmed
Holmes,
Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.
1990,
Pubmed
Jiricny,
A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.
1988,
Pubmed
Johnston,
Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase.
1978,
Pubmed
Jones,
Repair of a mismatch is influenced by the base composition of the surrounding nucleotide sequence.
1987,
Pubmed
Jones,
Mismatch repair of deaminated 5-methyl-cytosine.
1987,
Pubmed
Konrad,
Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase.
1973,
Pubmed
Kramer,
Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB.
1989,
Pubmed
Lahue,
Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction.
1987,
Pubmed
Lahue,
DNA mismatch correction in a defined system.
1989,
Pubmed
Leach,
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
1993,
Pubmed
Lieb,
Recombination in the lambda repressor gene: evidence that very short patch (VSP) mismatch correction restores a specific sequence.
1985,
Pubmed
Lu,
Repair of single base-pair transversion mismatches of Escherichia coli in vitro: correction of certain A/G mismatches is independent of dam methylation and host mutHLS gene functions.
1988,
Pubmed
Lu,
Methyl-directed repair of DNA base-pair mismatches in vitro.
1983,
Pubmed
Längle-Rouault,
GATC sequences, DNA nicks and the MutH function in Escherichia coli mismatch repair.
1987,
Pubmed
Modrich,
Mechanisms and biological effects of mismatch repair.
1991,
Pubmed
Petit,
Control of large chromosomal duplications in Escherichia coli by the mismatch repair system.
1991,
Pubmed
Prolla,
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.
1994,
Pubmed
Pukkila,
Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli.
1983,
Pubmed
Radicella,
Some mismatch repair activities in Escherichia coli.
1988,
Pubmed
Radman,
Mismatch recognition in chromosomal interactions and speciation.
1993,
Pubmed
Radman,
Replicational fidelity: mechanisms of mutation avoidance and mutation fixation.
1979,
Pubmed
Rayssiguier,
The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants.
1989,
Pubmed
Reenan,
Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.
1992,
Pubmed
Reitmair,
MSH2 deficient mice are viable and susceptible to lymphoid tumours.
1995,
Pubmed
Ross-Macdonald,
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction.
1994,
Pubmed
Shen,
Effect of base pair mismatches on recombination via the RecBCD pathway.
1989,
Pubmed
Stephenson,
Selective binding to DNA base pair mismatches by proteins from human cells.
1989,
Pubmed
Sternglanz,
Evidence that both growing DNA chains at a replication fork are synthesized discontinuously.
1976,
Pubmed
Stillman,
Smart machines at the DNA replication fork.
1994,
Pubmed
Stukenberg,
An explanation for lagging strand replication: polymerase hopping among DNA sliding clamps.
1994,
Pubmed
Thomas,
Heteroduplex repair in extracts of human HeLa cells.
1991,
Pubmed
Varlet,
DNA mismatch repair in Xenopus egg extracts: repair efficiency and DNA repair synthesis for all single base-pair mismatches.
1990,
Pubmed
,
Xenbase
Williamson,
Meiotic gene conversion mutants in Saccharomyces cerevisiae. I. Isolation and characterization of pms1-1 and pms1-2.
1985,
Pubmed
de Wind,
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.
1995,
Pubmed
