J Neurophysiol 1996 Sep 01;763:2089-92. doi: 10.1152/jn.1996.76.3.2089.

Glutamate and N-acetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via an mGluR2/3-like receptor.

???displayArticle.abstract???
1. We investigated the glutamate-mediated modulation of voltage-activated calcium currents in cultured interneurons of the olfactory bulb of Xenopus laevis, with the use of standard patch-clamp whole-cell recordings. 2. Glutamate and N-acetylaspartylglutamate (NAAG) activated (2S,1'R,2'R,3'R)-2-(2,3-dicarboxy-cyclopropyl)glycin-sens iti ve metabotropic glutamate receptors at olfactory bulb interneurons and thereby inhibited calcium influx through presynaptic voltage-gated calcium channels. 3. The glutamate- or NAAG-mediated blockage of calcium channels showed indistinguishable dose-response curves, with K1/2 = 388 and 350 nM for glutamate and NAAG, respectively. At saturating concentrations of glutamate or NAAG, approximately 40% of the maximum calcium currents were blocked. 4. It is concluded that glutamate, which excites interneurons at olfactory bulb reciprocal synapses, also causes a reduction of gamma-aminobutyric acid-mediated feedback inhibition at these synapses by activating a metabotropic-glutamate-receptor-2/3-like receptor.

???displayArticle.pubmedLink??? 8890318
???displayArticle.link??? J Neurophysiol