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An endogenous inactivating inward-rectifying potassium current in oocytes of Xenopus laevis.
Bauer CK
,
Falk T
,
Schwarz JR
.
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An endogenous inward-rectifying K+ current is described, which is present in native oocytes of some Xenopus laevis donors. Experiments were performed using defolliculated oocytes from donor frogs obtained from two different suppliers. In all oocytes from animals from one source, an inward-rectifying K+ current could be elicited with negative pulses from a holding potential of -20 mV in external solutions with a high K+ concentration. Increasing external K+ concentrations increased the amplitude of this current and shifted the reversal potential towards more positive potentials. In 118 mM KCl, the inward-rectifying K+ current partially inactivated between -20 and -80 mV and completely inactivated at more negative membrane potentials; 50% steady-state inactivation occurred near -50 mV. The time course of inactivation of the inward-rectifying current could be well fitted with two exponentials. The slow time constant had values of about 500 ms and was voltage independent. In contrast, the fast time constant and the time to reach the peak inward current decreased with more negative membrane potentials. Ba2+, Cs+, quinine (all 5 mM) and 50 mM tetraethylammonium partially blocked the inward-rectifying K+ current, whereas 10 mM 4-aminopyridine was without blocking effect. The oxidant chloramine-T blocked the inward-rectifying K+ current without slowing its inactivation.
Arcangeli,
A novel inward-rectifying K+ current with a cell-cycle dependence governs the resting potential of mammalian neuroblastoma cells.
1995, Pubmed
Arcangeli,
A novel inward-rectifying K+ current with a cell-cycle dependence governs the resting potential of mammalian neuroblastoma cells.
1995,
Pubmed
Barish,
A transient calcium-dependent chloride current in the immature Xenopus oocyte.
1983,
Pubmed
,
Xenbase
Bauer,
An inward-rectifying K+ current in clonal rat pituitary cells and its modulation by thyrotrophin-releasing hormone.
1990,
Pubmed
Biermans,
The mechanism of the inactivation of the inward-rectifying K current during hyperpolarizing steps in guinea-pig ventricular myocytes.
1987,
Pubmed
Bond,
Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic beta-cells and in the brain.
1995,
Pubmed
,
Xenbase
Brismar,
Inward rectifying potassium channels in human malignant glioma cells.
1989,
Pubmed
Corrette,
An inactivating inward-rectifying K current present in prolactin cells from the pituitary of lactating rats.
1996,
Pubmed
Cross,
A fast block to polyspermy in frogs mediated by changes in the membrane potential.
1980,
Pubmed
Dascal,
Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.
1993,
Pubmed
,
Xenbase
Dascal,
Xenopus oocyte resting potential, muscarinic responses and the role of calcium and guanosine 3',5'-cyclic monophosphate.
1984,
Pubmed
,
Xenbase
Dascal,
Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes.
1986,
Pubmed
,
Xenbase
Doupnik,
The inward rectifier potassium channel family.
1995,
Pubmed
Duprat,
Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers.
1995,
Pubmed
,
Xenbase
Eder,
Properties of voltage-gated currents of microglia developed using macrophage colony-stimulating factor.
1995,
Pubmed
Glowatzki,
Subunit-dependent assembly of inward-rectifier K+ channels.
1995,
Pubmed
,
Xenbase
Hedin,
Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes.
1996,
Pubmed
,
Xenbase
Hoyer,
Angiotensin II, vasopressin and GTP[gamma-S] inhibit inward-rectifying K+ channels in porcine cerebral capillary endothelial cells.
1991,
Pubmed
Huang,
Novel pharmacological properties of transient potassium currents in central neurons revealed by N-bromoacetamide and other chemical modifiers.
1995,
Pubmed
Ilschner,
Modulation of potassium currents in cultured murine microglial cells by receptor activation and intracellular pathways.
1995,
Pubmed
Kofuji,
Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.
1995,
Pubmed
,
Xenbase
Koumi,
Modulation of voltage-dependent inactivation of the inwardly rectifying K+ channel by chloramine-T.
1994,
Pubmed
Krapivinsky,
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.
1995,
Pubmed
,
Xenbase
Lewis,
Expression of an inwardly rectifying K+ channel from rat basophilic leukemia cell mRNA in Xenopus oocytes.
1991,
Pubmed
,
Xenbase
Lu,
A delayed rectifier potassium current in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Ma,
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Meyerhof,
A Rat Pituitary Tumour K(+) Channel Expressed in Frog Oocytes Induces a Transient K(+) Current Indistinguishable from that Recorded in Native Cells.
1992,
Pubmed
,
Xenbase
Miledi,
A calcium-dependent transient outward current in Xenopus laevis oocytes.
1982,
Pubmed
,
Xenbase
Parker,
Tetrodotoxin-sensitive sodium current in native Xenopus oocytes.
1987,
Pubmed
,
Xenbase
Parker,
A slowly inactivating potassium current in native oocytes of Xenopus laevis.
1990,
Pubmed
,
Xenbase
Parker,
A calcium-independent chloride current activated by hyperpolarization in Xenopus oocytes.
1988,
Pubmed
,
Xenbase
Preston,
Evidence for two K+ currents activated upon hyperpolarization of Paramecium tetraurelia.
1990,
Pubmed
Ransom,
Biophysical and pharmacological characterization of inwardly rectifying K+ currents in rat spinal cord astrocytes.
1995,
Pubmed
Ritchie,
Estrogen increases low voltage-activated calcium current density in GH3 anterior pituitary cells.
1993,
Pubmed
Schlief,
Modification of C-type inactivating Shaker potassium channels by chloramine-T.
1996,
Pubmed
,
Xenbase
Smith,
The inward rectification mechanism of the HERG cardiac potassium channel.
1996,
Pubmed
Trudeau,
HERG, a human inward rectifier in the voltage-gated potassium channel family.
1995,
Pubmed
Yang,
Characterization of stretch-activated ion channels in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Yoshii,
Inward rectifier produced by Xenopus oocytes injected with mRNA extracted from carp olfactory epithelium.
1989,
Pubmed
,
Xenbase
