On Friday November 24, 2017 around 5 pm EST portions of Xenbase may be intermittently available.

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-17819
Cell. August 23, 1996; 86 (4): 589-98.

Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.



Abstract
Chordin (Chd) is an abundant protein secreted by Spemann organizer tissue during gastrulation. Chd antagonizes signaling by mature bone morphogenetic proteins (BMPs) by blocking binding to their receptors. Recombinant Xenopus Chd binds to BMP-4 with high affinity (KD, 3 x 10(-10) M), binding specifically to BMPs but not to activin or TGF-beta1. Chd protein is able to dorsalize mesoderm and to neuralize ectoderm in Xenopus gastrula explants at 1 nM. We propose that the noncell-autonomous effects of Spemann''s organizer on dorsoventral patterning are executed in part by diffusible signals that directly bind to and neutralize ventral BMPs during gastrulation.

PubMed ID: 8752213
PMC ID: PMC3070603
Article link: Cell.
Grant support: HD21502-11 NICHD NIH HHS , R37 HD021502-13 NICHD NIH HHS , R37 HD021502 NICHD NIH HHS

Genes referenced: bmp4 chrd.1


References:
Aono, 1995, Pubmed, Xenbase[+]


My Xenbase: [ Log-in / Register ]
version: [4.6.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556