On Friday November 24, 2017 around 5 pm EST portions of Xenbase may be intermittently available.

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-17847
Nature. August 15, 1996; 382 (6592): 595-601.

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann''s organizer.

Bouwmeester T , Kim S , Sasai Y , Lu B , De Robertis EM .


Abstract
An abundant cDNA enriched in Spemann''s organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.

PubMed ID: 8757128
Article link: Nature.

Genes referenced: cer1



My Xenbase: [ Log-in / Register ]
version: [4.6.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556