Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann''s organizer.
An abundant cDNA enriched in Spemann''s organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.
PubMed ID: 8757128
Article link: Nature.
Genes referenced: cer1