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Nature. August 15, 1996; 382 (6592): 595-601.

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann''s organizer.

Bouwmeester T , Kim S , Sasai Y , Lu B , De Robertis EM .

An abundant cDNA enriched in Spemann''s organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.

PubMed ID: 8757128
Article link: Nature.

Genes referenced: cer1

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