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Xenopus connexin38 forms hemi-gap-junctional channels in the nonjunctional plasma membrane of Xenopus oocytes.
Ebihara L
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A nonselective cation current activated by depolarization (Ic) is present in the nonjunctional membrane of Xenopus oocytes. This current shares a number of properties with hemi-gap-junctional currents induced by exogenous gap-junctional proteins in oocytes and with a nonjunctional current seen in teleost retinal horizontal cells including nonselective permeability to small cations, block by external divalent cations, and slow activation kinetics. Here we study the effects of depleting or overexpressing Cx38 on Ic. Antisense depletion of Cx38 caused a marked reduction in Ic and blocked endogenous gap-junctional coupling in oocyte pairs. Conversely, expression of cloned Cx38 in oocytes increased the amplitude of Ic and enhanced gap-junctional coupling. Furthermore, there appeared to be a close correlation between the temperature sensitivity of Ic and the temperature sensitivity of assembly of endogenous gap-junctional channels in oocyte pairs. These results suggest that Xenopus connexin38 is involved in the generation of Ic.
Ackerman,
Hypotonicity activates a native chloride current in Xenopus oocytes.
1994, Pubmed,
Xenbase
Ackerman,
Hypotonicity activates a native chloride current in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Arellano,
A monovalent cationic conductance that is blocked by extracellular divalent cations in Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Barish,
A transient calcium-dependent chloride current in the immature Xenopus oocyte.
1983,
Pubmed
,
Xenbase
Barrio,
Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.
1991,
Pubmed
,
Xenbase
Beyer,
Connexin43: a protein from rat heart homologous to a gap junction protein from liver.
1987,
Pubmed
Bruzzone,
Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins.
1993,
Pubmed
,
Xenbase
DeVries,
Hemi-gap-junction channels in solitary horizontal cells of the catfish retina.
1992,
Pubmed
Ebihara,
Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytes.
1993,
Pubmed
,
Xenbase
Ebihara,
Distinct behavior of connexin56 and connexin46 gap junctional channels can be predicted from the behavior of their hemi-gap-junctional channels.
1995,
Pubmed
,
Xenbase
Ebihara,
Cloning and expression of a Xenopus embryonic gap junction protein.
1989,
Pubmed
,
Xenbase
Gimlich,
Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos.
1990,
Pubmed
,
Xenbase
Gupta,
Bovine connexin44, a lens gap junction protein: molecular cloning, immunologic characterization, and functional expression.
1994,
Pubmed
,
Xenbase
Hennemann,
Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung.
1992,
Pubmed
,
Xenbase
Hennemann,
Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs.
1992,
Pubmed
Hennemann,
Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin.
1992,
Pubmed
,
Xenbase
Kanter,
Cardiac myocytes express multiple gap junction proteins.
1992,
Pubmed
Krieg,
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.
1984,
Pubmed
,
Xenbase
Low,
Selective inhibition of protein targeting to the apical domain of MDCK cells by brefeldin A.
1992,
Pubmed
Methfessel,
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels.
1986,
Pubmed
,
Xenbase
Miledi,
A calcium-dependent transient outward current in Xenopus laevis oocytes.
1982,
Pubmed
,
Xenbase
Miledi,
Chloride current induced by injection of calcium into Xenopus oocytes.
1984,
Pubmed
,
Xenbase
Miller,
Post-Golgi membrane traffic: brefeldin A inhibits export from distal Golgi compartments to the cell surface but not recycling.
1992,
Pubmed
Parker,
A calcium-independent chloride current activated by hyperpolarization in Xenopus oocytes.
1988,
Pubmed
,
Xenbase
Paul,
Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes.
1991,
Pubmed
,
Xenbase
Spray,
Equilibrium properties of a voltage-dependent junctional conductance.
1981,
Pubmed
,
Xenbase
White,
Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70.
1992,
Pubmed
,
Xenbase
Willecke,
Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung.
1991,
Pubmed
,
Xenbase
Yang,
Characterization of stretch-activated ion channels in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Zhang,
Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA.
1989,
Pubmed
