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XB-ART-17921
Development August 1, 1996; 122 (8): 2385-94.

Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4.

Ladher R , Mohun TJ , Smith JC , Snape AM .


Abstract
Bone morphogenetic protein-4 (BMP-4) is thought to play an important role in early Xenopus development by acting as a "ventralizing factor'' and as an epidermal determinant: local inhibition of BMP-4 function in whole embryos causes the formation of an additional dorsal axis, and inhibition of BMP-4 function in isolated ectodermal cells causes the formation of neural tissue. In this paper we describe a homeobox-containing gene whose expression pattern is similar to that of BMP-4, whose expression requires BMP-4 signalling and which, when over-expressed, causes a phenotype similar to that caused by over-expression of BMP-4. We suggest that this gene, which we call Xom, acts downstream of BMP-4 to mediate its effects.

PubMed ID: 8756284
Article link: Development

Genes referenced: actc1 actl6a bmp2 bmp4 fgf2 hba4 il17f nog odc1 tbxt ventx2.2


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