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XB-ART-17962
Biochem Biophys Res Commun 1996 Jul 16;2242:406-13. doi: 10.1006/bbrc.1996.1040.
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cDNA cloning and expression of the Xenopus laevis vitellogenin receptor.

Okabayashi K , Shoji H , Nakamura T , Hashimoto O , Asashima M , Sugino H .


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A Xenopus laevis oocyte cDNA library was screened with a PCR-generated X. laevis vitellogenin (VTG) receptor probe and a 3.6 kb cDNA clone containing the entire open reading frame, and 5' and 3' noncoding regions were isolated. The deduced amino acid sequence was 72% homologous to the chicken VLDL/VTG receptor, and the characteristic domains were highly conserved. Ligand binding analysis confirmed that the cloned receptor was Xenopus VTG-specific. Although Northern blotting analysis revealed that this gene was expressed as a major transcript of 3.6 kb in Xenopus ovary, weak but significant expression was observed in other tissues by RT-PCR analysis. The fact that major expression of the gene occurs in the ovary suggests that it has an important function in this organ.

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Species referenced: Xenopus laevis
Genes referenced: vldlr