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XB-ART-1797
Dev Cell June 1, 2005; 8 (6): 843-54.

Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets.

Park JI , Kim SW , Lyons JP , Ji H , Nguyen TT , Cho K , Barton MC , Deroo T , Vleminckx K , Moon RT , McCrea PD .


Abstract
Beta-catenin-dependent or canonical Wnt signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kaiso directly represses canonical Wnt gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to beta-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kaiso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased beta-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kaiso suppression of beta-catenin-induced axis duplication and by TCF-3 rescue of Kaiso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and beta-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.

PubMed ID: 15935774
Article link: Dev Cell
Grant support: [+]
Genes referenced: ctnnd1 dct fos h4c4 myc nodal3.1 nodal3.2 sia1 sult2a1 tbxt tcf7l1 wnt11b zbtb16 zbtb33
Morpholinos: ctnnd1 MO1 ctnnd1 MO2 sult4a1 MO1 zbtb33 MO1


Article Images: [+] show captions
References :
Gumbiner, Coordinate gene regulation by two different catenins. 2005, Pubmed, Xenbase


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