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Dev Biol July 10, 1996; 177 (1): 96-103.

Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus.

Danos MC , Yost HJ .

The left-right body axis is coordinately aligned with the orthogonal dorsoventral and anterioposterior body axes. The developmental mechanisms that regulate axis coordination are unknown. Here it is shown that the cardiac left-right orientation in zebrafish (Danio rerio) is randomized in notochord-defective no tail and floating head mutants. no tail (Brachyury) and floating head (Xnot) encode putative transcription factors that are expressed in the organizer and notochord, structures which regulate dorsoventral and anterioposterior development in vertebrate embryos. Results from dorsal tissue extirpation and cardiac primordia explantation indicate that cardiac left-right orientation is dependent on dorsoanterior structures including the notochord and is specified during neural fold stages in Xenopus laevis. Thus, the notochord coordinates the development of all three body axes in the vertebrate body plan.

PubMed ID: 8660880
Article link: Dev Biol

Genes referenced: col2a1 myh1 not tbxt
Antibodies: Myh1 Ab1

Article Images: [+] show captions

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