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FEBS Lett March 25, 1996; 383 (1-2): 26-30.

Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes.

Robertson B , Owen D , Stow J , Butler C , Newland C .

We have examined the effects of two DTX homologues, toxin I and toxin K, on Kv1.1, Kv1.2 and Kv1.6 channels expressed in Xenopus oocytes. Toxin I blocked all three channels; in contrast, toxin K was selective for Kv1.1. Both toxins slowed channel activation and inactivation kinetics with 10 nM toxin I approximately doubling activation and inactivation time constants of Kv1.1. For the first time, we have demonstrated the selectivity of a DTX homologue for a single cloned Kv1 channel and suggest that these toxins may sterically hinder the conformational changes that occur during channel gating.

PubMed ID: 8612784
Article link: FEBS Lett

Species referenced: Xenopus
Genes referenced: dtx1 kcna1 kcna2 kcna6