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XB-ART-18646
FEBS Lett 1996 Jan 15;3783:227-31.
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Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2.

Badman MK , Shennan KI , Jermany JL , Docherty K , Clark A .


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Islet amyloid polypeptide (IAPP), 'amylin', is the component peptide of islet amyloid formed in Type 2 diabetes. IAPP is expressed in islet beta-cells and is derived from a larger precursor, proIAPP, by proteolysis. An in vitro translation/translocation system was used to separately examine processing of human proIAPP by the beta-cell endopeptidases PC2, PC3 or furin. ProIAPP was converted to mature IAPP by PC2 but there was little conversion by furin or PC3. These data are consistent with processing of proIAPP in beta-cell secretory granules. Abnormal cellular proteolysis associated with type 2 diabetes could contribute to IAPP amyloidosis.

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Species referenced: Xenopus
Genes referenced: btg2 furin iapp iappl pcsk2 pkd2