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Dev Dyn July 1, 2005; 233 (3): 1123-30.
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Expression of Xenopus suppressor of cytokine signaling 3 (xSOCS3) is induced by epithelial wounding.

Kuliyev E , Doherty JR , Mead PE .

The suppressor of cytokine signaling (SOCS) family of proteins are intracellular mediators of cytokine signaling. These proteins are induced rapidly by cytokine stimulation and act in a classic negative-feedback loop to attenuate the cellular response to the cytokine signal. In this study, we present the cloning and initial characterization of the Xenopus SOCS3 gene. We show that xSOCS3 is rapidly induced in response to epithelial wounding in the tadpole. The induction of xSOCS3 in response to trauma is transient with maximal expression being reached 1 hr after the injury and diminishing after that. Unlike other genes known to be responsive to wound-induced activation of the mitogen-activated protein (MAP) kinase pathway, such as Egr1, SOCS3 expression in response to trauma is unaffected by blockade of the MAP kinase pathway by chemical inhibitors.

PubMed ID: 15906371
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bag3 egr1 grap2 jak2 map2k1 mapk1 socs3

Article Images: [+] show captions