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XB-ART-18687
Perspect Dev Neurobiol January 1, 1996; 4 (2-3): 205-13.

Calcium and chemotropic turning of nerve growth cones.

Zheng JQ , Poo MM , Connor JA .


Abstract
Cultured Xenopus spinal neurons exhibit chemotropic turning toward the source of neurotransmitters acetylcholine and glutamate. Here we review the experimental evidence that transmitter-induced turning of the growth cone is mediated by an influx of Ca2+, that a gradient of intracellular Ca2+ within the growth cone is responsible for the directional growth cone response, and that asymmetric filopodia formation precedes and is essential for the turning response.

PubMed ID: 9168203
Article link:



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