Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-18953
Biophys J 1995 Dec 01;696:2449-57.
Show Gene links Show Anatomy links

Cooperative subunit interactions in C-type inactivation of K channels.

Ogielska EM , Zagotta WN , Hoshi T , Heinemann SH , Haab J , Aldrich RW .


???displayArticle.abstract???
C-type inactivation of potassium channels is distinct from N-terminal mediated (N-type) inactivation and involves a closing of the outer mouth of the channel. We have investigated the role of the individual subunits of the tetrameric channel in the C-type inactivation conformational change by comparing the inactivation rates of channels constructed from different combinations of subunits. The relationship between the inactivation rate and the number of fast subunits is exponential, as would be predicted by a cooperative mechanism where the C-type conformational change involves all four subunits, and rules out a mechanism where a conformational change in any of the individual subunits is sufficient for inactivation. Subunit interactions in C-type inactivation are further supported by an interaction between separate mutations affecting C-type inactivation when in either the same or separate subunits.

???displayArticle.pubmedLink??? 8599651
???displayArticle.pmcLink??? PMC1236482
???displayArticle.link??? Biophys J
???displayArticle.grants??? [+]


References [+] :
Adelman, The effects of external potassium and long duration voltage conditioning on the amplitude of sodium currents in the giant axon of the squid, Loligo pealei. 1969, Pubmed