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The amino-terminal tails of the core histones and the translational position of the TATA box determine TBP/TFIIA association with nucleosomal DNA.
Godde JS
,
Nakatani Y
,
Wolffe AP
.
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We establish that the TATA binding protein (TBP) in the presence of TFIIA recognizes the TATA box in nucleosomal DNA dependent on the dissociation of the amino-terminal tails of the core histones from the nucleosome and the position of the TATA box within the nucleosome. We examine TBP/TFIIA access to the TATA box with this sequence placed in four distinct rotational frames with reference to the histone surface and at three distinct translational positions at the edge, side and dyad axis of the nucleosome. Under our experimental conditions, we find that the preferential translational position at which TBP/TFIIA can bind the TATA box is within linker DNA at the edge of the nucleosome and that binding is facilitated if contacts made by the amino-terminal tails of the histones with nucleosomal DNA are eliminated. TBP/TFIIA binding to DNA at the edge of the nucleosome occurs with the TATA box in all four rotational positions. This is indicative of TBP/TFIIA association directing the dissociation of the TATA box from the surface of the histone octamer.
Archer,
Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.
1991, Pubmed
Archer,
Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.
1991,
Pubmed
Ausio,
Use of selectively trypsinized nucleosome core particles to analyze the role of the histone "tails" in the stabilization of the nucleosome.
1989,
Pubmed
Ausio,
Nucleosome core particle stability and conformational change. Effect of temperature, particle and NaCl concentrations, and crosslinking of histone H3 sulfhydryl groups.
1984,
Pubmed
Bashkin,
Structure of DNA in a nucleosome core at high salt concentration and at high temperature.
1993,
Pubmed
,
Xenbase
Buratowski,
Five intermediate complexes in transcription initiation by RNA polymerase II.
1989,
Pubmed
Cary,
Effect of acetylation on the binding of N-terminal peptides of histone H4 to DNA.
1982,
Pubmed
Chen,
A histone-binding protein, nucleoplasmin, stimulates transcription factor binding to nucleosomes and factor-induced nucleosome disassembly.
1994,
Pubmed
Cormack,
The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells.
1992,
Pubmed
Dong,
DNA and protein determinants of nucleosome positioning on sea urchin 5S rRNA gene sequences in vitro.
1990,
Pubmed
Han,
Depletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae.
1988,
Pubmed
Hayes,
The structure of DNA in a nucleosome.
1990,
Pubmed
,
Xenbase
Hayes,
Histone contributions to the structure of DNA in the nucleosome.
1991,
Pubmed
,
Xenbase
Hayes,
The histone core exerts a dominant constraint on the structure of DNA in a nucleosome.
1991,
Pubmed
Hayes,
Histones H2A/H2B inhibit the interaction of transcription factor IIIA with the Xenopus borealis somatic 5S RNA gene in a nucleosome.
1992,
Pubmed
,
Xenbase
Hayes,
Preferential and asymmetric interaction of linker histones with 5S DNA in the nucleosome.
1993,
Pubmed
,
Xenbase
Hayes,
Contacts of the globular domain of histone H5 and core histones with DNA in a "chromatosome".
1994,
Pubmed
,
Xenbase
Hoffmann,
Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies.
1991,
Pubmed
Horikoshi,
Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box.
1989,
Pubmed
Horikoshi,
Transcription factor TFIID induces DNA bending upon binding to the TATA element.
1992,
Pubmed
Imbalzano,
Facilitated binding of TATA-binding protein to nucleosomal DNA.
1994,
Pubmed
Kahn,
DNA bending in transcription initiation.
1993,
Pubmed
Kim,
Co-crystal structure of TBP recognizing the minor groove of a TATA element.
1993,
Pubmed
Kim,
Crystal structure of a yeast TBP/TATA-box complex.
1993,
Pubmed
Kim,
Involvement of the basic repeat domain of TATA-binding protein (TBP) in transcription by RNA polymerases I, II, and III.
1994,
Pubmed
Kladde,
Positioned nucleosomes inhibit Dam methylation in vivo.
1994,
Pubmed
Knezetic,
The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro.
1986,
Pubmed
,
Xenbase
Lee,
A positive role for histone acetylation in transcription factor access to nucleosomal DNA.
1993,
Pubmed
,
Xenbase
Li,
Translational positioning of a nucleosomal glucocorticoid response element modulates glucocorticoid receptor affinity.
1993,
Pubmed
Lorch,
Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones.
1987,
Pubmed
Maldonado,
Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.
1990,
Pubmed
Matsui,
Transcription of adenovirus 2 major late and peptide IX genes under conditions of in vitro nucleosome assembly.
1987,
Pubmed
Meisterernst,
Recombinant yeast TFIID, a general transcription factor, mediates activation by the gene-specific factor USF in a chromatin assembly assay.
1990,
Pubmed
,
Xenbase
Nightingale,
Methylation at CpG sequences does not influence histone H1 binding to a nucleosome including a Xenopus borealis 5 S rRNA gene.
1995,
Pubmed
,
Xenbase
Nikolov,
Crystal structure of TFIID TATA-box binding protein.
1992,
Pubmed
Patterton,
Nucleosomal location of the STE6 TATA box and Mat alpha 2p-mediated repression.
1994,
Pubmed
Pennings,
Mobility of positioned nucleosomes on 5 S rDNA.
1991,
Pubmed
Perlmann,
Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome.
1988,
Pubmed
Piña,
Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter.
1990,
Pubmed
Pruss,
Histone-DNA contacts in a nucleosome core containing a Xenopus 5S rRNA gene.
1993,
Pubmed
,
Xenbase
Pruss,
Nucleosomal anatomy--where are the histones?
1995,
Pubmed
Ranish,
Isolation of two genes that encode subunits of the yeast transcription factor IIA.
1992,
Pubmed
Rhodes,
Structural analysis of a triple complex between the histone octamer, a Xenopus gene for 5S RNA and transcription factor IIIA.
1985,
Pubmed
,
Xenbase
Richmond,
Studies of nucleosome structure.
1993,
Pubmed
Ura,
A positive role for nucleosome mobility in the transcriptional activity of chromatin templates: restriction by linker histones.
1995,
Pubmed
,
Xenbase
Vettese-Dadey,
Role of the histone amino termini in facilitated binding of a transcription factor, GAL4-AH, to nucleosome cores.
1994,
Pubmed
Wolffe,
Initiation of transcription on nucleosomal templates.
1989,
Pubmed
Wolffe,
A bacteriophage RNA polymerase transcribes through a Xenopus 5S RNA gene transcription complex without disrupting it.
1986,
Pubmed
,
Xenbase
Workman,
Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II.
1987,
Pubmed
,
Xenbase
Yamashita,
Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIB.
1992,
Pubmed
,
Xenbase
Yamashita,
Transcription factor TFIIB sites important for interaction with promoter-bound TFIID.
1993,
Pubmed
