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J Biol Chem November 24, 1995; 270 (47): 28297-303.

Sequence-specific RNA recognition by the Xenopus Y-box proteins. An essential role for the cold shock domain.

Bouvet P , Matsumoto K , Wolffe AP .

The Xenopus Y-box protein FRGY2 has a role in the translational silencing of masked maternal mRNA. Here, we determine that FRGY2 will recognize specific RNA sequences. The evolutionarily conserved nucleic acid-binding cold shock domain is required for sequence-specific interactions with RNA. However, RNA binding by FRGY2 is facilitated by N- and C-terminal regions flanking the cold shock domain. The hydrophilic C-terminal tail domain of FRGY2 interacts with RNA independent of the cold shock domain but does not determine sequence specificity. Thus, both sequence-specific and nonspecific RNA recognition domains are contained within the FRGY2 protein.

PubMed ID: 7499328
Article link: J Biol Chem

Species referenced: Xenopus
Genes referenced: ybx2