XB-ART-19006
Gene
1995 Nov 20;1652:319-20. doi: 10.1016/0378-1119(95)00544-g.
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Identification of non-tissue-specific helix-loop-helix genes in Xenopus laevis.
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We have isolated four non-tissue-specific helix-loop-helix (HLH) transcription factors from Xenopus laevis (Xl). While some are clearly orthologous to known mammalian HLH proteins, others have dramatic amino-acid differences in otherwise highly conserved protein domains. We propose that these changes arose following the tetraploidization of Xl approx. 30 Myr ago.
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Species referenced: Xenopus laevis
Genes referenced: tcf12 tcf3 tcf4