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XB-ART-19016
J Biol Chem 1995 Nov 17;27046:27411-4. doi: 10.1074/jbc.270.46.27411.
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Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel.

Waldmann R , Champigny G , Bassilana F , Voilley N , Lazdunski M .


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We have isolated a cDNA for a novel human amiloride-sensitive Na+ channel isoform (called delta) which is expressed mainly in brain, pancreas, testis, and ovary. When expressed in Xenopus oocytes, it generates an amiloride-sensitive Na+ channel with biophysical and pharmacological properties distinct from those of the epithelial Na+ channel, a multimeric assembly of alpha, beta, and gamma subunits. The Na+ current produced by the new delta isoform is increased by two orders of magnitude after coexpression of the beta and gamma subunit of the epithelial Na+ channel showing that delta can associate with other subunits and is part of a novel multisubunit ion channel.

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???displayArticle.link??? J Biol Chem