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Ann N Y Acad Sci April 1, 2005; 1040 95-105.

In situ hybridization localization of TRH precursor and TRH receptor mRNAs in the brain and pituitary of Xenopus laevis.

Galas L , Bidaud I , Bulant M , Jenks BG , Ouwens DT , Jégou S , Ladram A , Roubos EW , Nicolas P , Tonon MC , Vaudry H .

We examined the distribution of the mRNAs encoding proTRH and the three TRH receptor subtypes (xTRHR1, xTRHR2, and xTRHR3) in the Xenopus laevis CNS and pituitary. A positive correlation was generally observed between the expression patterns of proTRH and xTRHR mRNAs. xTRHRs were widely expressed in the telencephalon and diencephalon, where two or even three xTRHR mRNAs were often simultaneously observed within the same brain structures. In the pituitary, xTRHR2 was selectively expressed in the distal lobe, and xTRHR3 was found exclusively in the intermediate lobe of white background-adapted animals, indicating that, in amphibians, the effect of TRH on alpha-melanotropin (alpha-MSH) secretion from melanotrope cells is mediated through the novel receptor subtype xTRHR3.

PubMed ID: 15891012
Article link: Ann N Y Acad Sci

Species referenced: Xenopus
Genes referenced: pomc trh trhr trhr2