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Development August 1, 1995; 121 (8): 2349-60.

Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage.

Lai CJ , Ekker SC , Beachy PA , Moon RT .

The patterns of embryonic expression and the activities of Xenopus members of the hedgehog gene family are suggestive of role in neural induction and patterning. We report that these hedgehog polypeptides undergo autoproteolytic cleavage. Injection into embryos of mRNAs encoding Xenopus banded-hedgehog (X-bhh) or the amino-terminal domain (N) demonstrates that the direct inductive activities of X-bhh are encoded by N. In addition, both N and X-bhh pattern neural tissue by elevating expression of anterior neural genes. Unexpectedly, an internal deletion of X-bhh (delta N-C) was found to block the activity of X-bhh and N in explants and to reduce dorsoanterior structures in embryos. As elevated hedgehog activity increases the expression of anterior neural genes, and as delta N-C reduces dorsoanterior structures, these complementary data support a role for hedgehog in neural induction and anteroposterior patterning.

PubMed ID: 7671801
Article link: Development
Grant support: [+]
Genes referenced: acta4 actl6a ag1 dhh egr2 en2 gsc hesx1 hoxa9 hoxb9 ihh inhba ncam1 nog nrp1 otx2 prl.1 shh tbx2 tbxt wnt8a
Antibodies: Ihh Ab1

Article Images: [+] show captions

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