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Nature June 29, 1995; 375 (6534): 761-6.

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta.

Chitnis A , Henrique D , Lewis J , Ish-Horowicz D , Kintner C .

X-Delta-1, a Xenopus homologue of the Drosophila Delta gene, is expressed in the early embryonic nervous system in scattered cells that appear to be the prospective primary neurons. Ectopic X-Delta-1 activity inhibits production of primary neurons and interference with endogenous X-Delta-1 activity results in overproduction of primary neurons. These results indicate that the X-Delta-1 protein mediates lateral inhibition delivered by prospective neurons to adjacent cells, and that commitment to a neural fate in vertebrates is regulated by Delta-Notch signalling as in Drosophila.

PubMed ID: 7596407
Article link: Nature

Genes referenced: dll1 notch1

References :
Simpson, Developmental genetics. The Notch connection. 1995, Pubmed

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