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XB-ART-19646
Curr Opin Cell Biol 1995 Jun 01;73:329-36.
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The SMC family: from chromosome condensation to dosage compensation.

Hirano T , Mitchison TJ , Swedlow JR .


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Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.

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