Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Environ Health Perspect
1995 May 01;103 Suppl 4:19-25. doi: 10.1289/ehp.95103s419.
Show Gene links
Show Anatomy links
Vitellogenin induction by xenobiotic estrogens in the red-eared turtle and African clawed frog.
Palmer BD
,
Palmer SK
.
???displayArticle.abstract???
Many environmental pollutants have estrogenic activity in animals. Xenobiotic estrogens include many pesticides and industrial chemicals that biocumulate. The impact of these common pollutants on the reproductive success of wildlife may be considerable, particularly in threatened or endangered species. This research examined the use of plasma vitellogenin in males as a biomarker for estrogenic xenobiotics in reptiles and amphibians. Adult male turtles (Trachemys scripta) and frogs (Xenopus laevis) were given ip injections of estradiol-17 beta (E2), diethylstilbestrol (DES), or o,p'-DDT (1-chloro-2-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzene) daily for 7 days, and plasma was collected on day 14. The estrogenic activity of each compound was determined by measuring the induction of plasma vitellogenin. Vitellogenin was identified by precipitation, electrophoresis, Western blot, and enzyme-linked immunosorbant assay (ELISA). In both species, estradiol and DES treatments induced the most vitellogenin, whereas DDT treatments induced smaller amounts of vitellogenin in a dose-dependent fashion. These data indicate that induction of plasma vitellogenin in males may be a useful biomarker of xenobiotic estrogen activity in wild populations of reptiles and amphibians.
Arai,
Cancer development in male reproductive tract in rats given diethylstilbestrol at neonatal age.
1978, Pubmed
Arai,
Cancer development in male reproductive tract in rats given diethylstilbestrol at neonatal age.
1978,
Pubmed
Bern,
Long-term alterations in histology and steroid receptor levels of the genital tract and mammary gland following neonatal exposure of female BALB/cCrgl mice to various doses of diethylstilbestrol.
1987,
Pubmed
Bishop,
The case for a cause-effect linkage between environmental contamination and development in eggs of the common snapping turtle (Chelydra S.serpentina) from Ontario, Canada.
1991,
Pubmed
Bradley,
Vitellogenin induction by estradiol in channel catfish, Ictalurus punctatus.
1989,
Pubmed
Bulger,
Estrogenic action of DDT analogs.
1983,
Pubmed
Clark,
DDE residues and artificial incubation of loggerhead sea turtle eggs.
1985,
Pubmed
Colborn,
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
1993,
Pubmed
Crews,
Estrogen and sex reversal in turtles: a dose-dependent phenomenon.
1991,
Pubmed
Driscoll,
Effects of prenatal maternal estrogen on the male urogenital system.
1980,
Pubmed
Fry,
DDT-induced feminization of gull embryos.
1981,
Pubmed
Goodwin,
Monoclonal antibody-based immunoassay of vitellogenin in the blood of male channel catfish (Ictalurus punctatus).
1992,
Pubmed
Gorski,
Perturbations in the model of estrogen receptor regulation of gene expression.
1993,
Pubmed
Guillette,
Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida.
1994,
Pubmed
Herbst,
Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.
1971,
Pubmed
Ho,
Effect of exogenous estradiol-17beta on plasma vitellogenin levels in male and female Chrysemys and its modulation by testosterone and progesterone.
1981,
Pubmed
Ho,
Effect of hypophysectomy and growth hormone on estrogen-induced vitellogenesis in the freshwater turtle, Chrysemys picta.
1982,
Pubmed
Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed
Le Guellec,
Vitellogenin gene expression in male rainbow trout (Salmo gairdneri).
1988,
Pubmed
,
Xenbase
McBlain,
The levo enantiomer of o,p'-DDT inhibits the binding of 17 beta-estradiol to the estrogen receptor.
1987,
Pubmed
McKim,
Polychlorinated biphenyls and p,p'-DDE in Loggerhead and Green postyearling Atlantic sea turtles.
1983,
Pubmed
McLachlan,
Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol.
1975,
Pubmed
McLachlan,
Estrogens and development.
1987,
Pubmed
Morales,
Vitellogenesis in Anolis pulchellus: induction of VTG-like protein in liver explants from male and immature lizards.
1991,
Pubmed
,
Xenbase
Pakdel,
In vivo estrogen induction of hepatic estrogen receptor mRNA and correlation with vitellogenin mRNA in rainbow trout.
1991,
Pubmed
Pelissero,
Vitellogenin synthesis in cultured hepatocytes; an in vitro test for the estrogenic potency of chemicals.
1993,
Pubmed
Riegel,
Differential induction of hepatic estrogen receptor and vitellogenin gene transcription in Xenopus laevis.
1987,
Pubmed
,
Xenbase
Shapiro,
Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.
1967,
Pubmed
Sundararaj,
Steroid-induced synthesis of vitellogenin in the catfish, Heteropneustes fossilis (Bloch).
1981,
Pubmed
Tata,
Vitellogenesis: a versatile model for hormonal regulation of gene expression.
1979,
Pubmed
,
Xenbase
Tata,
The expression of the vitellogenin gene.
1976,
Pubmed
,
Xenbase
Tousignant,
Effect of exogenous estradiol applied at different embryonic stages on sex determination, growth, and mortality in the leopard gecko (Eublepharis macularius).
1994,
Pubmed
Towbin,
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
1979,
Pubmed
Vaillant,
Vitellogenin gene expression in primary culture of male rainbow trout hepatocytes.
1988,
Pubmed
Wahli,
Vitellogenin in Xenopus laevis is encoded in a small family of genes.
1979,
Pubmed
,
Xenbase
Wake,
Declining amphibian populations.
1991,
Pubmed
Wangh,
Synthesis of vitellogenin in cultures of male and female frog liver regulated by estradiol treatment in vitro.
1975,
Pubmed
,
Xenbase
Wiley,
New methods for the purification of vertebrate vitellogenin.
1979,
Pubmed
,
Xenbase
