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Nature April 13, 1995; 374 (6523): 617-22.

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.

He X , Saint-Jeannet JP , Woodgett JR , Varmus HE , Dawid IB .

Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3), which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early Xenopus development. It was found that dominant-negative GSK-3 mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization. These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless/wnt-related signal.

PubMed ID: 7715701
Article link: Nature

Species referenced: Xenopus laevis
Genes referenced: gsk3b gys1