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Dev Biol April 1, 1995; 168 (2): 694-7.

Tannahill D , Bray S , Harris WA .

A Drosophila Enhancer of split [E(spl)] bHLH protein, m delta, was misexpressed in Xenopus embryos along with green fluorescent protein (GFP) as a lineage label. The Drosophila protein translocated to the nucleus of Xenopus cells and led to neural hypertrophy in the GFP-labeled dorsal ectoderm, a phenotype similar to that caused by the misexpression of activated Xotch. Our data indicate a strong conservation in E(spl)bHLH function in the Notch signaling pathway of flies and vertebrates.

PubMed ID: 7729602
Article link: Dev Biol

Genes referenced: notch1

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