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Cell February 10, 1995; 80 (3): 473-83.

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development.

Tang TL , Freeman RM , O'Reilly AM , Neel BG , Sokol SY .

SH-PTP2, the vertebrate homolog of Drosophila corkscrew, associates with several activated growth factor receptors, but its biological function is unknown. We assayed the effects of injection of wild-type and mutant SH-PTP2 RNAs on Xenopus embryogenesis. An internal phosphatase domain deletion (delta P) acts as a dominant negative mutant, causing severe posterior truncations. This phenotype is rescued by SH-PTP2, but not by the closely related SH-PTP1. In ectodermal explants, delta P blocks fibroblast growth factor (FGF)- and activin-mediated induction of mesoderm and FGF-induced mitogen-activated protein (MAP) kinase activation. Our results indicate that SH-PTP2 is required for early vertebrate development, acting as a positive component in FGF signaling downstream of the FGF receptor and upstream of MAP kinase.

PubMed ID: 7859288
Article link: Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: acta4 actc1 fgf2 fn1 inhba mapk1 ptpru tbxt

Article Images: [+] show captions