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XB-ART-2040
Neuron April 7, 2005; 46 (1): 23-36.

Frizzled 5 signaling governs the neural potential of progenitors in the developing Xenopus retina.

Van Raay TJ , Moore KB , Iordanova I , Steele M , Jamrich M , Harris WA , Vetter ML .


Abstract
Progenitors in the developing central nervous system acquire neural potential and proliferate to expand the pool of precursors competent to undergo neuronal differentiation. The formation and maintenance of neural-competent precursors are regulated by SoxB1 transcription factors, and evidence that their expression is regionally regulated suggests that specific signals regulate neural potential in subdomains of the developing nervous system. We show that the frizzled (Fz) transmembrane receptor Xfz5 selectively governs neural potential in the developing Xenopus retina by regulating the expression of Sox2. Blocking either Xfz5 or canonical Wnt signaling within the developing retina inhibits Sox2 expression, reduces cell proliferation, inhibits the onset of proneural gene expression, and biases individual progenitors toward a nonneural fate, without altering the expression of multiple progenitor markers. Blocking Sox2 function mimics these effects. Rescue experiments indicate that Sox2 is downstream of Xfz5. Thus, Fz signaling can regulate the neural potential of progenitors in the developing nervous system.

PubMed ID: 15820691
Article link: Neuron
Grant support: [+]
Genes referenced: ascl2 atoh7 dll1 fzd5 neurog2 notch1 pax6 rho rlbp1 rpe six3 six6 sox2 tcf7l1 vsx2
Morpholinos: fzd5 MO1 fzd5 MO2 sox2 MO2


Article Images: [+] show captions


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