was isolated by differential screening. The
gene encodes a novel protein of 941 amino acids that has a signal sequence and four Cys-rich domains. The expression of
, and its induction by activin requires de novo protein synthesis. Microinjection of
mRNA induces twinned axes and can completely rescue axial development in ventralized embryos. This molecule is a potent dorsalizing factor that is expressed at the
Amaya, Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. 1991,
Pubmed,
Xenbase
Blumberg, Organizer-specific homeobox genes in Xenopus laevis embryos. 1991,
Pubmed,
Xenbase
Bornstein, Thrombospondins: structure and regulation of expression. 1992,
Pubmed
Cho, Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. 1992,
Pubmed,
Xenbase
Christian, Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. 1993,
Pubmed,
Xenbase
Christian, Xwnt-8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm. 1992,
Pubmed,
Xenbase
Cunliffe, Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8. 1994,
Pubmed,
Xenbase
Dirksen, A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain. 1992,
Pubmed,
Xenbase
Gont, Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip. 1994,
Pubmed,
Xenbase
Gurdon, Injected nuclei in frog oocytes: fate, enlargement, and chromatin dispersal. 1977,
Pubmed,
Xenbase
Harland, In situ hybridization: an improved whole-mount method for Xenopus embryos. 1992,
Pubmed,
Xenbase
Hunt, von Willebrand factor shares a distinctive cysteine-rich domain with thrombospondin and procollagen. 1987,
Pubmed
Kao, The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos. 1988,
Pubmed,
Xenbase
Keller, Early embryonic development of Xenopus laevis. 1992,
Pubmed,
Xenbase
Keller, Vital dye mapping of the gastrula and neurula of Xenopus laevis. II. Prospective areas and morphogenetic movements of the deep layer. 1976,
Pubmed,
Xenbase
McMahon, Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. 1989,
Pubmed,
Xenbase
Moon, Competence modifiers synergize with growth factors during mesoderm induction and patterning in Xenopus. 1992,
Pubmed,
Xenbase
Niehrs, The homeobox gene goosecoid controls cell migration in Xenopus embryos. 1993,
Pubmed,
Xenbase
Niehrs, Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid. 1994,
Pubmed,
Xenbase
Rebagliati, Identification and cloning of localized maternal RNAs from Xenopus eggs. 1985,
Pubmed,
Xenbase
Rosa, Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos. 1989,
Pubmed,
Xenbase
Ruiz i Altaba, Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis. 1993,
Pubmed,
Xenbase
Sasai, Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. 1993,
Pubmed
Serafini, The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. 1994,
Pubmed
Sive, A simple subtractive hybridization technique employing photoactivatable biotin and phenol extraction. 1989,
Pubmed
Slack, Inductive effects of fibroblast growth factor and lithium ion on Xenopus blastula ectoderm. 1989,
Pubmed,
Xenbase
Smith, Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. 1991,
Pubmed,
Xenbase
Smith, Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. 1992,
Pubmed,
Xenbase
Smith, Biochemical specificity of Xenopus notochord. 1985,
Pubmed,
Xenbase
Smith, Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. 1991,
Pubmed,
Xenbase
Smith, Mesoderm-inducing factors in early vertebrate development. 1993,
Pubmed
Smith, Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm. 1993,
Pubmed,
Xenbase
Sokol, Injected Wnt RNA induces a complete body axis in Xenopus embryos. 1991,
Pubmed,
Xenbase
Spemann, 2019,
Pubmed
Steinbeisser, Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs. 1993,
Pubmed,
Xenbase
Stewart, The anterior extent of dorsal development of the Xenopus embryonic axis depends on the quantity of organizer in the late blastula. 1990,
Pubmed,
Xenbase
Tadano, Differential induction of regulatory genes during mesoderm formation in Xenopus laevis embryos. 1993,
Pubmed,
Xenbase
Taira, The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. 1992,
Pubmed,
Xenbase
Thomsen, Processed Vg1 protein is an axial mesoderm inducer in Xenopus. 1993,
Pubmed,
Xenbase
Wright, Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord. 1989,
Pubmed,
Xenbase
von Dassow, Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. 1993,
Pubmed,
Xenbase
