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XB-ART-20674
Science 1994 Oct 14;2665183:282-5.
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Microtubule severing by elongation factor 1 alpha.

Shiina N , Gotoh Y , Kubomura N , Iwamatsu A , Nishida E .


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An activity that severs stable microtubules is thought to be involved in microtubule reorganization during the cell cycle. Here, a 48-kilodalton microtubule-severing protein was purified from Xenopus eggs and identified as translational elongation factor 1 alpha (EF-1 alpha). Bacterially expressed human EF-1 alpha also displayed microtubule-severing activity in vitro and, when microinjected into fibroblasts, induced rapid and transient fragmentation of cytoplasmic microtubule arrays. Thus, EF-1 alpha, an essential component of the eukaryotic translational apparatus, appears to have a second role as a regulator of cytoskeletal rearrangements.

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Species referenced: Xenopus laevis
Genes referenced: eef1a1