Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
CGRP-induced activation of KATP channels in follicular Xenopus oocytes.
Guillemare E
,
Lazdunski M
,
Honoré E
.
???displayArticle.abstract???
The two-microelectrode voltage-clamp technique was used to monitor K+ channel activity in Xenopus oocyte follicular cells, which are electrically coupled to the oocyte itself by gap junctions. Endogenous vasodilators such as calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), prostaglandin E2 (PGE2) and adenosine activate glibenclamide-ATP-sensitive K+ (KATP) channels in Xenopus oocyte follicular cells. The mechanism of action of CGRP was studied in detail. CGRP effects undergo a rapid desensitization. CGRP acts via CGRPI receptors. Its effects are antagonised by the amino-truncated CGRP analog hCGRP(8-37). The second messenger for CGRP activation of KATP channels is cAMP. Phosphodiesterase inhibition by 3-isobutyl-1-methylxanthine enhances the CGRP response while adenyl cyclase inhibition by either 2',5'-dideoxyadenosine or progesterone nearly completely depresses the CGRP response. Vasoconstrictors such as ACh and angiotensin II also have receptors in follicular cells. ACh strongly inhibits the CGRP activation of K+ channels as it inhibits the activation of KATP channels by P1060, but angiotensin II does not. It is concluded that as in vascular smooth muscle cells, CGRP and probably other hyperpolarizing vasodilators open KATP channels in follicular cells by protein kinase A activation.
Amara,
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.
1982, Pubmed
Amara,
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.
1982,
Pubmed
Beech,
Single channel and whole-cell K-currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein.
1993,
Pubmed
Bhogal,
Molecular identification of binding sites for calcitonin gene-related peptide (CGRP) and islet amyloid polypeptide (IAPP) in mammalian lung: species variation and binding of truncated CGRP and IAPP.
1993,
Pubmed
Bonev,
Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth muscle.
1993,
Pubmed
Brain,
Calcitonin gene-related peptide is a potent vasodilator.
,
Pubmed
Brayden,
Regulation of arterial tone by activation of calcium-dependent potassium channels.
1992,
Pubmed
Cavero,
Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels.
1989,
Pubmed
Cook,
Intracellular ATP directly blocks K+ channels in pancreatic B-cells.
,
Pubmed
Dascal,
The use of Xenopus oocytes for the study of ion channels.
1987,
Pubmed
,
Xenbase
Donoso,
Pharmacological characterization of CGRP1 receptor subtype in the vascular system of the rat: studies with hCGRP fragments and analogs.
1990,
Pubmed
Dunne,
Potassium selective ion channels in insulin-secreting cells: physiology, pharmacology and their role in stimulus-secretion coupling.
1991,
Pubmed
Edvinsson,
Calcitonin gene-related peptide and cerebral blood vessels: distribution and vasomotor effects.
1987,
Pubmed
Guillemare,
Functional receptors in Xenopus oocytes for U-37883A, a novel ATP-sensitive K+ channel blocker: comparison with rat insulinoma cells.
1994,
Pubmed
,
Xenbase
Honoré,
Two different types of channels are targets for potassium channel openers in Xenopus oocytes.
1991,
Pubmed
,
Xenbase
Honoré,
Hormone-regulated K+ channels in follicle-enclosed oocytes are activated by vasorelaxing K+ channel openers and blocked by antidiabetic sulfonylureas.
1991,
Pubmed
,
Xenbase
Honoré,
Single-channel properties and regulation of pinacidil/glibenclamide-sensitive K+ channels in follicular cells from Xenopus oocyte.
1993,
Pubmed
,
Xenbase
Johnson,
Cation and structural requirements for P site-mediated inhibition of adenylate cyclase.
1989,
Pubmed
Kajioka,
Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein.
1991,
Pubmed
Kitazono,
Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo.
1993,
Pubmed
Miledi,
Effects of defolliculation on membrane current responses of Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Miledi,
Membrane currents elicited by prostaglandins, atrial natriuretic factor and oxytocin in follicle-enclosed Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Miller,
Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle.
,
Pubmed
Morrill,
Changes in cyclic AMP levels in the amphibian ovarian follicle following progesterone induction of meiotic maturation. Effect of phosphodiesterase inhibitors and exogenous calcium on germinal vesicle breakdown.
1977,
Pubmed
Nelson,
Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels.
1990,
Pubmed
Nelson,
Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone.
1990,
Pubmed
Okabe,
Actions of cromakalim on ionic currents recorded from single smooth muscle cells of the rat portal vein.
1990,
Pubmed
Okimura,
Calcitonin gene-related peptide-like immunoreactivity in the central nervous system and peripheral organs of rats.
1987,
Pubmed
Parent,
Reconstitution of the ATP-sensitive potassium channel of skeletal muscle. Activation by a G protein-dependent process.
1989,
Pubmed
Quast,
Do the K+ channel openers relax smooth muscle by opening K+ channels?
1993,
Pubmed
Quast,
Moving together: K+ channel openers and ATP-sensitive K+ channels.
1989,
Pubmed
Quayle,
Calcitonin gene-related peptide activated ATP-sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A.
1994,
Pubmed
Schmid-Antomarchi,
The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.
1987,
Pubmed
Standen,
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
1989,
Pubmed
Stevenson,
Increased concentration of circulating calcitonin gene related peptide during normal human pregnancy.
1986,
Pubmed
Terzic,
G proteins activate ATP-sensitive K+ channels by antagonizing ATP-dependent gating.
1994,
Pubmed
Wibrand,
Opening of glibenclamide-sensitive K+ channels in follicular cells promotes Xenopus oocyte maturation.
1992,
Pubmed
,
Xenbase
