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XB-ART-21355
Proc Natl Acad Sci U S A 1994 Apr 26;919:3882-6.
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Synapsin IIa accelerates functional development of neuromuscular synapses.

Schaeffer E , Alder J , Greengard P , Poo MM .


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We have investigated the possible involvement of the synaptic vesicle protein synapsin IIa in synapse development. Synapsin IIa was introduced into Xenopus embryonic spinal neurons by early blastomere injection, and nerve-muscle cultures were prepared. Synaptic currents were measured by comparing synapses in which the presynaptic neuron either contained [syn IIa (+)] or lacked (control) exogenous synapsin IIa. Syn IIa (+) synapses had a 3.6-fold increase in the frequency and a 2.1-fold increase in the amplitude of spontaneous synaptic currents, compared to controls, after 2 days in culture. Synapsin IIa also increased the amplitude of evoked synaptic currents by 2.3-fold in 2-day cultures. The evoked synaptic current amplitudes of syn IIa (+) synapses had a lower coefficient of variation indicating a more stable evoked response. These enhanced synaptic activities were independent of the presence or absence of the protein in the postsynaptic muscle cell. The findings indicate a role for synapsin IIa in synapse maturation.

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Species referenced: Xenopus laevis
Genes referenced: syn1

References [+] :
Anderson, Effects of innervation on the distribution of acetylcholine receptors on cultured muscle cells. 1977, Pubmed, Xenbase