XB-ART-21476
Biochem Biophys Res Commun
1994 Mar 15;1992:552-63. doi: 10.1006/bbrc.1994.1264.
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Regulated expression of Brachyury(T), Nkx1.1 and Pax genes in embryoid bodies.
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Embryonic stem cells (ES) can be exploited to analyze in vitro mechanisms of cellular differentiation. We have utilized ES-derived embryoid body formation in an attempt to study cell types resulting from in vitro differentiation. To this end, a variety of molecular markers, preferably those which have been associated with regulatory events during mouse embryogenesis, was employed. Specifically, Brachyury (T), Pax-3 and Pax-6 genes as well as Nkx-1.1 were used. We could demonstrate that the expression of these genes in vitro was regulated by growth factors such as activin A or bFGF. Implications of these findings and the possible applications for identifying new genes are discussed.
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Species referenced: Xenopus
Genes referenced: fgf2 inhba nkx1-1 pax3 pax6 tbxt