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XB-ART-21794
Adv Second Messenger Phosphoprotein Res 1994 Jan 01;29:521-7. doi: 10.1016/s1040-7952(06)80033-9.
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Activity-dependent modulation of developing neuromuscular synapses.

Poo MM .


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Spontaneous and impulse-evoked synaptic currents were observed immediately following nerve-muscle contact in Xenopus cell cultures. The functional significance of this early synaptic activity was examined. Stimulation of pre- and/or post-synaptic cells was found to exert immediate and persistent effects on the efficacy of synaptic transmission. Exogenous application of calcitonin gene-related peptide (CGRP) and neurotrophins, factors that may be coreleased with ACh in activity-dependent manner at the developing neuromuscular junctions, also modulate either the postsynaptic ACh response or presynaptic ACh release. These results underscore the plasticity of developing neuromuscular synapses and suggest a complex interplay between electrical activity and chemical factors during the formation and maturation of neuronal connections.

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Species referenced: Xenopus
Genes referenced: calca