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XB-ART-22580
Nature May 27, 1993; 363 (6427): 350-3.

Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF.

Lohof AM , Ip NY , Poo MM .


Abstract
The neurotrophins are a family of neurotrophic factors that promote survival and differentiation of various neuronal populations. Although the long-term effects of neurotrophins on neuronal survival and differentiation have been intensively studied, nothing is known about their effects on synaptic function. Here we report that acute exposure to neurotrophin-3 (NT-3) or brain-derived neurotrophic factor (BDNF), but not nerve growth factor (NGF), rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture. The effect appears to be presynaptic in origin and to be mediated by the Trk family of receptor tyrosine kinases. These results provide evidence for the regulation of the function of developing synapses by neurotrophins.

PubMed ID: 8497318
Article link: Nature

Genes referenced: bdnf ngf ntf3



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