XB-ART-22603FEBS Lett May 3, 1993; 322 (1): 6-9.
Chaperonins dependent increase of Cu,Zn superoxide dismutase production in Escherichia coli.
Over-expression of the chaperonins GroEL and GroES significantly suppressed the temperature-dependent pattern of expression of Cu,Zn superoxide dismutases in Escherichia coli and increased the yield of active enzyme. The results obtained indicate that chaperonins prevent degradation of metal-deficient enzyme molecules. GroEL was shown to form a complex with unfolded Cu,Zn superoxide dismutase in vitro, confirming that GroEL can interact with beta-stranded proteins.
PubMed ID: 8097729
Article link: FEBS Lett
Species referenced: Xenopus
Genes referenced: hspd1