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XB-ART-22603
FEBS Lett May 3, 1993; 322 (1): 6-9.

Chaperonins dependent increase of Cu,Zn superoxide dismutase production in Escherichia coli.

Battistoni A , Carri MT , Steinkühler C , Rotilio G .


Abstract
Over-expression of the chaperonins GroEL and GroES significantly suppressed the temperature-dependent pattern of expression of Cu,Zn superoxide dismutases in Escherichia coli and increased the yield of active enzyme. The results obtained indicate that chaperonins prevent degradation of metal-deficient enzyme molecules. GroEL was shown to form a complex with unfolded Cu,Zn superoxide dismutase in vitro, confirming that GroEL can interact with beta-stranded proteins.

PubMed ID: 8097729
Article link: FEBS Lett


Species referenced: Xenopus
Genes referenced: hspd1