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XB-ART-2262
Dev Dyn. April 1, 2005; 232 (4): 979-91.

XTbx1 is a transcriptional activator involved in head and pharyngeal arch development in Xenopus laevis.

Ataliotis P , Ivins S , Mohun TJ , Scambler PJ .


Abstract
The development of pharyngeal arch derivatives in mouse and zebrafish embryos depends on the activity of the transcription factor Tbx1. We cloned the Xenopus laevis orthologue of Tbx1 (XTbx1) and show that the pattern of expression is similar to that in other vertebrate species. Zygotic transcripts are first detected shortly after the mid-blastula transition and are localized to the presumptive mesoderm at mid-gastrula stages. XTbx1 expression persists in the lateral plate mesoderm at neurula stages and is found in the pharyngeal arches and otic vesicles from early tail bud stages onward. We demonstrate that XTbx1 is a transcriptional activator and that this trans-activation requires the C-terminal region of the protein. A dominant interfering mutant of XTbx1 disrupts the development of Xenopus head structures and pharyngeal arch derivatives. Lineage labeling reveals a requirement for XTbx1 function in cells that contribute to the pharyngeal mesoderm and for fgf8 expression.

PubMed ID: 15736267
Article link: Dev Dyn.
Grant support: MRC_MC_U117562103 Medical Research Council , MC_U117562103 Medical Research Council

Genes referenced: actc1 fgf8 tbx1

OMIMs referenced: DIGEORGE SYNDROME; DGS [+]


Article Images: [+] show captions

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