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Proc Natl Acad Sci U S A May 1, 1993; 90 (9): 3948-52.

Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.

Clevidence DE , Overdier DG , Tao W , Qian X , Pani L , Lai E , Costa RH .

Hepatocyte nuclear factor (HNF)-3 alpha, -3 beta, and -3 gamma are liver transcription factors that mediate the coordinate expression of a number of hepatocyte-specific genes. The HNF-3 proteins share DNA-binding-domain homology among themselves and with the Drosophila homeotic protein forkhead (fkh). The HNF-3/fkh DNA-binding domain constitutes an uncharacterized protein motif that recognizes its cognate DNA binding site as a monomer. Additional HNF-3/fkh-related proteins are known to be required for determination events during embryogenesis in Drosophila and Xenopus. In this report, we describe the isolation of nine additional HNF-3/fkh homologue (HFH) clones from rodent tissue cDNAs by using both low-stringency hybridization and a polymerase chain reaction protocol. Many of the HFH genes exhibit a tissue-restricted expression pattern and are transcribed in tissues other than liver, including brain, kidney, lung, and intestine. The HNF-3/fkh motif therefore comprises a large gene family of transcription factors that play a role in tissue-specific gene regulation and development.

PubMed ID: 7683413
PMC ID: PMC46423
Article link: Proc Natl Acad Sci U S A
Grant support: [+]
Genes referenced: foxa4

References [+] :
Akira, A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. 1990, Pubmed

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