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XB-ART-22760
Nature March 4, 1993; 362 (6415): 31-8.

Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.

Ho K , Nichols CG , Lederer WJ , Lytton J , Vassilev PM , Kanazirska MV , Hebert SC .


Abstract
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.

PubMed ID: 7680431
Article link: Nature



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