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XB-ART-22782
J Neurochem 1993 Mar 01;603:1175-8. doi: 10.1111/j.1471-4159.1993.tb03273.x.
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Stable expression and regulation of a rat brain K+ channel.

Critz SD , Wible BA , Lopez HS , Brown AM .


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The Shaw-type K+ channel Kv3.1 was stably transfected in human embryonic kidney cells. Voltage dependence of activation, K+ permeability, sensitivity to external tetraethylammonium, and unitary conductance were similar to Kv3.1 channels expressed transiently in Xenopus oocytes. Kv3.1 channels appear to be regulated because the protein kinase C activator phorbol 12,13-dibutyrate decreased Kv3.1 currents. Based on these results, we find that the stable expression of voltage-gated K+ channels in human embryonic kidney cells appears to be well suited for analysis of both biophysical and biochemical regulatory processes.

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Species referenced: Xenopus
Genes referenced: kcnc3