Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-22872
Mol Cell Biol 1993 Feb 01;132:1290-5. doi: 10.1128/mcb.13.2.1290-1295.1993.
Show Gene links Show Anatomy links

Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes.

Dominguez I , Sanz L , Arenzana-Seisdedos F , Diaz-Meco MT , Virelizier JL , Moscat J .


???displayArticle.abstract???
Nuclear factor kappa B (NF-kappa B) plays a critical role in the regulation of a large variety of cellular genes. However, the mechanism whereby this nuclear factor is activated remains to be determined. In this report, we present evidence that in oocytes from Xenopus laevis, (i) ras p21- and phospholipase C (PLC)-mediated phosphatidylcholine (PC) hydrolysis activates NF-kappa B and (ii) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC. Thus, the microinjection of either ras p21 or PC-PLC, or the exposure of oocytes to insulin, promotes a significant translocation to the nucleus of an NF-kappa B-like activity. This effect is not observed when oocytes are incubated with phorbol myristate acetate or progesterone, both of which utilize a ras p21-independent pathway for oocyte activation. These data strongly suggest a critical role of the insulin/ras p21/PC-PLC/protein kinase C zeta pathway in the control of NF-kappa B activation.

???displayArticle.pubmedLink??? 8423794
???displayArticle.pmcLink??? PMC359014
???displayArticle.link??? Mol Cell Biol


Species referenced: Xenopus laevis
Genes referenced: cdkn1a ins pc.1

References [+] :
Arenzana-Seisdedos, c-Ha-ras transfection induces human immunodeficiency virus (HIV) transcription through the HIV-enhancer in human fibroblasts and astrocytes. 1989, Pubmed