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Neuron February 1, 1993; 10 (2): 137-49.

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.

Ip NY , Stitt TN , Tapley P , Klein R , Glass DJ , Fandl J , Greene LA , Barbacid M , Yancopoulos GD .

We have exploited a battery of approaches to address several controversies that have accompanied the expansion of the nerve growth factor (NGF) family of neurotrophic factors and the identification of the Trk tyrosine kinases as receptors for these factors. For example, we find that a recently cloned mammalian neurotrophin, known as either neurotrophin-4 or neurotrophin-5 and assigned widely differing receptor specificities, represents the functional counterpart of Xenopus neurotrophin-4 and is a "preferred" ligand for TrkB. However, its interactions with TrkB can be distinguished from those of brain-derived neurotrophic factor (BDNF) with TrkB. We also find that all of the Trks display similar dose responses to their "preferred" ligands in neuronal as compared with nonneuronal cells (i.e., NGF for TrkA, BDNF and NT-4/5 for TrkB, and NT-3 for TrkC), providing evidence against a role for accessory molecules expressed in neurons in generating receptors that would allow for responses to lower concentrations of the neurotrophins. However, we find that a neuronal environment does restrict the Trks in their ability to respond to their "nonpreferred" neurotrophin ligands.

PubMed ID: 7679912
Article link: Neuron
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bdnf ngf ntf3 ntf4 ntrk1 ntrk2 ntrk3