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Nature October 8, 1992; 359 (6395): 500-5.

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.

Galzi JL , Devillers-ThiƩry A , Hussy N , Bertrand S , Changeux JP , Bertrand D .

Introduction by site-directed mutagenesis of three amino acids from the MII segment of glycine or gamma-aminobutyric acid (GABAA) receptors into the MII segment of alpha 7 nicotinic receptor was sufficient to convert a cation-selective channel into an anion-selective channel gated by acetylcholine. A critical mutation was the insertion of an uncharged residue at the amino-terminal end of MII, stressing the importance of protein geometrical constraints on ion selectivity.

PubMed ID: 1383829
Article link: Nature

Genes referenced: gabarap

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