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XB-ART-2331
Dev Biol. March 1, 2005; 279 (1): 179-92.

Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus.

Garriock RJ , D'Agostino SL , Pilcher KC , Krieg PA .


Abstract
Wnt11 is a secreted protein that signals through the non-canonical planar cell polarity pathway and is a potent modulator of cell behavior and movement. In human, mouse, and chicken, there is a single Wnt11 gene, but in zebrafish and Xenopus, there are two genes related to Wnt11. The originally characterized Xenopus Wnt11 gene is expressed during early embryonic development and has a critical role in regulation of gastrulation movements. We have identified a second Xenopus Wnt11-Related gene (Wnt11-R) that is expressed after gastrulation. Sequence comparison suggests that Xenopus Wnt11-R, not Wnt11, is the ortholog of mammalian and chicken Wnt11. Xenopus Wnt11-R is expressed in neural tissue, dorsal mesenchyme derived from the dermatome region of the somites, the brachial arches, and the muscle layer of the heart, similar to the expression patterns reported for mouse and chicken Wnt11. Xenopus Wnt11-R exhibits biological properties similar to those previously described for Xenopus Wnt11, in particular the ability to activate Jun-N-terminal kinase (JNK) and to induce myocardial marker expression in ventral marginal zone (VMZ) explants. Morpholino inhibition experiments demonstrate, however, that Wnt11-R is not required for cardiac differentiation, but functions in regulation of cardiac morphogenesis. Embryos with reduced Wnt11-R activity exhibit aberrant cell-cell contacts within the myocardial wall and defects in fusion of the nascent heart tube.

PubMed ID: 15708567
Article link: Dev Biol.
Grant support: HL63926 NHLBI NIH HHS

Genes referenced: jun krt2l mapk8 wnt11 wnt11b zmym3

Morpholinos referenced: krt2l MO1 wnt11 MO1 zmym3 MO1


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