Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Calcium sensitizing action of carnosine and other endogenous imidazoles in chemically skinned striated muscle.
Lamont C
,
Miller DJ
.
???displayArticle.abstract???
1. The imidazole-containing compounds carnosine and homocarnosine, endogenous to skeletal and cardiac muscle, have been tested for effect on the contractile behaviour of chemically skinned (saponin or Triton X-100) skeletal and cardiac muscle. 2. Carnosine, at millimolar concentrations which are near physiological for many skeletal fibres, and in a concentration-dependent fashion, shifts the curve relating [Ca2+] to steady-state tension to lower [Ca2+] in both skeletal (frog but not crab) and cardiac (rat) muscle preparations. 3. Of other imidazoles endogenous to heart, homocarnosine is somewhat more effective, while N-acetyl L-histidine is much less so. 4. The maximum level of Ca(2+)-activated force is increased significantly by homocarnosine in cardiac trabeculae. 5. We propose that the cellular imidazoles related to carnosine are natural 'Ca2+ sensitizers' in striated muscle. Alterations in their levels as a result of disease or training, and between different fibre types, may contribute to differences in contractile performance of the intact tissues.
Altringham,
Effects of phosphate on the contractile properties of fast and slow muscle fibres from an Antarctic fish.
1985, Pubmed
Altringham,
Effects of phosphate on the contractile properties of fast and slow muscle fibres from an Antarctic fish.
1985,
Pubmed
Avena,
Effects of carnosine and anserine on muscle adenosine triphosphatases.
1969,
Pubmed
Brown,
Interactions among carnosine, anserine, ophidine and copper in biochemical adaptation.
1981,
Pubmed
Burton,
The composition of animal cells: solutes contributing to osmotic pressure and charge balance.
1983,
Pubmed
Chapman,
Structure-activity relations for caffeine: a comparative study of the inotropic effects of the methylxanthines, imidazoles and related compounds on the frog's heart.
1974,
Pubmed
Crush,
Carnosine and related substances in animal tissues.
1970,
Pubmed
DAVEY,
The significance of carnosine and anserine in striated skeletal muscle.
1960,
Pubmed
Fabiato,
Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricle.
1981,
Pubmed
Fink,
Potassium and ionic strength effects on the isometric force of skinned twitch muscle fibres of the rat and toad.
1986,
Pubmed
Fisher,
Anserine and carnosine in chicks (Gallus gallus) rat pups (Rattus rattus) and ducklings (Anas platyrhynchos): comparative ontogenetic observations.
1977,
Pubmed
Gercken,
[Myocardial protection by a carnosine-buffered cardioplegic solution (author's transl)].
1980,
Pubmed
Good,
Hydrogen ion buffers for biological research.
1966,
Pubmed
HASSELBACH,
Models for the study of the contraction of muscle and of cell protoplasm.
1955,
Pubmed
Harrison,
Hysteresis and the length dependence of calcium sensitivity in chemically skinned rat cardiac muscle.
1988,
Pubmed
Helenius,
Solubilization of membranes by detergents.
1975,
Pubmed
Herzig,
Activating effects of AR-L 115 BS on the Ca2+ sensitive force, stiffness and unloaded shortening velocity (Vmax) in isolated contractile structures from mammalian heart muscle.
1981,
Pubmed
Huddart,
Superprecipitation of actomyosin extracted from crayfish skeletal muscle: the effect of heavy metal cations, EDTA and drugs.
1971,
Pubmed
Jaquet,
Influence of association and of positive inotropic drugs on calcium binding to cardiac troponin C.
1987,
Pubmed
Johnson,
Effects of carnosine and anserine on muscle and non-muscle phosphorylases.
1984,
Pubmed
KOREY,
Some factors influencing the contractility of a non-conducting fiber preparation.
1950,
Pubmed
Kentish,
The inhibitory effects of monovalent ions on force development in detergent-skinned ventricular muscle from guinea-pig.
1984,
Pubmed
Kuroda,
N-acetylhistidine isolated from frog heart.
1966,
Pubmed
Lopina,
[Effect of the dipeptides carnosine and anserine on the accumulation of Ca2+ by sarcoplasmic reticulum fragments].
1975,
Pubmed
Macefield,
Perceptual responses to microstimulation of single afferents innervating joints, muscles and skin of the human hand.
1990,
Pubmed
Miller,
EGTA purity and the buffering of calcium ions in physiological solutions.
1984,
Pubmed
Miller,
Calcium release by caffeine and other methylxanthines in skinned skeletal muscle fibres [proceedings].
1977,
Pubmed
Miller,
The 'calcium sensitising' effects of ORG30029 in saponin- or Triton-skinned rat cardiac muscle.
1990,
Pubmed
Miller,
The contractile behaviour of EGTA- and detergent-treated heart muscle.
1985,
Pubmed
O'Dowd,
Detection, characterisation, and quantification of carnosine and other histidyl derivatives in cardiac and skeletal muscle.
1988,
Pubmed
Parker,
A comparative study of the effect of carnosine on myofibrillar-ATPase activity of vertebrate and invertebrate muscles.
1970,
Pubmed
Rochel,
Carnosine release from olfactory bulb synaptosomes is calcium-dependent and depolarization-stimulated.
1982,
Pubmed
Severin,
[Physiological activity of natural derivatives of imidazole].
1976,
Pubmed
Smith,
Potentiometric measurements of stoichiometric and apparent affinity constants of EGTA for protons and divalent ions including calcium.
1985,
Pubmed
Sobue,
Isolation and identification of N-acetylhomocarnosine and N-acetylcarnosine from brain and muscle.
1975,
Pubmed
Solaro,
Stimulation of Ca++ binding and ATPase activity of dog cardiac myofibrils by AR-L 115BS, a novel cardiotonic agent.
1982,
Pubmed
Stepanova,
[Carnosine and anserine content of muscles in the course of progressive muscular dystrophy].
1968,
Pubmed
Stephenson,
Calcium-activated force responses in fast- and slow-twitch skinned muscle fibres of the rat at different temperatures.
1981,
Pubmed
Wendt,
Effects of caffeine on Ca-activated force production in skinned cardiac and skeletal muscle fibres of the rat.
1983,
Pubmed
